From Route 283 and Route 30
 

Take the Rt. 501S Exit (Lititz Pike) or Rt. 272S (Oregon Pike) and follow signs for Downtown Lancaster. Proceed on Route 501S/272S over the bridge. Once across the bridge, you will approach a traffic light. Stay in the left lane and continue straight on to North Duke St.

Immediately after the traffic light, you will find the entrance to the St. Anne Church parking lot on the left-hand side of Duke St. Look for brick pillars marking the entrance to the lot.

There are two doors off the lot for entering the church. One door is accessed by a ramp from the parking lot. It is wheelchair accessible; and, there are two designated handicapped parking spaces located adjacent to the ramp entrance.